That’s a really good question. Because there are lots of factors that you’d think will affect it, but they don’t.
But the basic answer is yes it will sound the same.
There are some very small effects caused by things like the lower air density; but these don’t affect it enough to hear the difference usually. Most of the differences though are because it’s difficult to play in the microgravity conditions experienced on the ISS.
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This is a good video of Chris Hadfiled playing his guitar on the ISS.
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